Reconstituted High-Density Lipoprotein Therapies

Reconstituted high-density lipoprotein therapies: a cause for optimism.

Nanobiotechnology applications of reconstituted high density lipoprotein

High-density lipoprotein (HDL) plays a fundamental role in the Reverse Cholesterol Transport pathway. Prior to maturation, nascent HDL exist as disk-shaped phospholipid bilayers whose perimeter is stabilized by amphipathic apolipoproteins. Methods have been developed to generate reconstituted (rHDL) in vitro and these particles have been used in a variety of novel ways. To differentiate between...

Therapies for raising high-density lipoprotein cholesterol.

A low high-density lipoprotein cholesterol (HDL-C) level is one of the strongest predictors of coronary risk (1). The negative correlation between coronary artery disease (CAD) and plasma HDL-C has been attributed to the ability of HDL to take up cellular cholesterol from the periphery and to mediate the transport of excess cholesterol to the liver (reverse cholesterol transport, RCT) (2). In J...

Reconstituted High-Density Lipoprotein Modulates Activation of Human Leukocytes

An anti-inflammatory effect of reconstituted High Density Lipoprotein (rHDL) has been demonstrated in atherosclerosis and in sepsis models. An increase of adhesion molecules as well as tissue factor expression on endothelial cells in response to inflammatory or danger signals are attenuated by the treatment with rHDL. Here we show the inhibitory effect of rHDL on the activation of human leukocy...

Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia

High-density lipoprotein (HDL) has been found to neutralize LPS activity in vitro and in animals in vivo. We sought to determine the effects of reconstituted HDL (rHDL) on LPS responsiveness in humans in a double-blind, randomized, placebo-controlled, cross-over study. rHDL, given as a 4-h infusion at 40 mg/kg starting 3.5 h before endotoxin challenge (4 ng/kg), reduced flu-like symptoms during...